We are, in a real sense, still a single-celled organism: we abide by the rules for which that unity came to exist, how it continues to exist, and what it means to exist. Autopoiesis is the term used for a self-making unity. From the very beginning there has been something which we can call the seed of cognition. This is how the organism is structurally and dynamically in relationship to the environment, and knowledge is how it has adapted to be better coupled, more resilient to variables. The continued existence of the organism relies on the accuracy or truthfulness of these couplings, which are doomed to myopia, just as we are doomed to mortality. The exploration of the biological origins of cognition can have profound implications for how we define knowledge and its purpose, and how we sin or “miss the mark.”